<?xml version="1.0" encoding="UTF-8"?><RequestOrchestration xmlns="http://hl7.org/fhir">
  <id value="kdn5-example"/>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml">Administer gemcitabine and carboplatin.</div>
  </text>
  <contained>
    <MedicationRequest>
      <id value="1111"/>
      <status value="unknown"/>
      <intent value="proposal"/>
      <medication>
      <concept>
        <coding>
          <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
          <code value="12574"/>
          <display value="gemcitabine"/>
        </coding>
        <text value="gemcitabine"/>
      </concept>
      </medication>
      <subject>
        <reference value="Patient/example"/>
      </subject>
      <dosageInstruction>
        <text value="1250 mg/m² IV over 30 minutes"/>
        <timing>
          <repeat>
            <duration value="30"/>
            <durationUnit value="min"/>
          </repeat>
        </timing>
        <route>
          <text value="IV"/>
        </route>
        <doseAndRate>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/>
              <code value="ordered"/>
              <display value="Ordered"/>
            </coding>
          </type>
          <doseQuantity>
          <value value="1250"/>
          <unit value="mg/m²"/>
          </doseQuantity>
        </doseAndRate>
      </dosageInstruction>
    </MedicationRequest>
  </contained>
  <contained>
    <MedicationRequest>
      <id value="2222"/>
      <status value="unknown"/>
      <intent value="proposal"/>
      <medication>
      <concept>
        <coding>
          <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
          <code value="40048"/>
          <display value="Carboplatin"/>
        </coding>
        <text value="CARBOplatin"/>
      </concept>
      </medication>
      <subject>
        <reference value="Patient/example"/>
      </subject>
      <dosageInstruction>
        <text value="AUC 5 IV over 30 minutes"/>
        <timing>
          <repeat>
            <duration value="30"/>
            <durationUnit value="min"/>
          </repeat>
        </timing>
        <route>
          <text value="IV"/>
        </route>
        <doseAndRate>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/>
              <code value="ordered"/>
              <display value="Ordered"/>
            </coding>
          </type>
          <doseQuantity>
              <!--  AUC as dose unit or as an extension?  -->
            <extension url="http://example.org/fhir/AUC-dose">
              <valueInteger value="5"/>
            </extension>
              <!--  <value value="5" />
          <unit value="AUC" />
          <system value="http://snomed.info/sct" />
          <code value="413573002" />  -->
          </doseQuantity>
        </doseAndRate>

      </dosageInstruction>
    </MedicationRequest>
  </contained>
  <identifier>
    <value value="requestorchestration-kdn5"/>
  </identifier>
  <instantiatesCanonical value="http://example.org/fhir/PlanDefinition/KDN5"/>
  <status value="draft"/>
  <intent value="plan"/>
  <priority value="routine"/>
  <subject>
    <reference value="Patient/example"/>
  </subject>
  <encounter>
    <reference value="Encounter/example"/>
  </encounter>
  <authoredOn value="2017-03-06T17:31:00Z"/>
  <author>
    <reference value="Practitioner/1"/>
  </author>

  <action>
      <!--  list of regimen options. in this case only one  -->
    <selectionBehavior value="exactly-one"/>
    <action>
        <!--  list of regimen parts. in this case only one  -->
      <selectionBehavior value="all"/>
      <action>
          <!--  list of cycle definitions. in this case only one  -->
        <groupingBehavior value="sentence-group"/>
        <selectionBehavior value="exactly-one"/>
        <action id="cycle-definition-1">
          <textEquivalent value="21-day cycle for 6 cycles"/>

          <timingTiming>
            <repeat>
              <count value="6"/>
              <duration value="21"/>
              <durationUnit value="d"/>
            </repeat>
          </timingTiming>

            <!--  list of regimen entry references for this regimen part  -->
            <!--  references would duplicated in each cycle definition option
          (see codesystem-action-grouping-behavior.html#sentence-group) -->
          <action id="action-1">
            <extension url="http://hl7.org/fhir/StructureDefinition/timing-daysOfCycle">
              <extension url="day">
                <valueInteger value="1"/>
              </extension>
              <extension url="day">
                <valueInteger value="8"/>
              </extension>
            </extension>
            <textEquivalent value="Gemcitabine 1250 mg/m² IV over 30 minutes on days 1 and 8"/>
            <resource>
              <reference value="#1111"/>
            </resource>
          </action>
          <action id="action-2">
            <extension url="http://hl7.org/fhir/StructureDefinition/timing-daysOfCycle">
              <extension url="day">
                <valueInteger value="1"/>
              </extension>
            </extension>
            <textEquivalent value="CARBOplatin AUC 5 IV over 30 minutes on Day 1"/>
            <relatedAction>
              <targetId value="action-1"/>
              <relationship value="concurrent-with-start"/>
			</relatedAction>
            <resource>
              <reference value="#2222"/>
            </resource>
          </action>   <!--  end of regimen entries  -->
        </action>   <!--  end of cycle definitions  -->
      </action>   <!--  end of regimen parts  -->
    </action>   <!--  end of regimen options  -->
  </action>
</RequestOrchestration>