<?xml version="1.0" encoding="UTF-8"?><Evidence xmlns="http://hl7.org/fhir">
  <id value="example-stroke-alteplase-fatalICH"/>
  <meta>
    <security>
      <system value="http://terminology.hl7.org/CodeSystem/v3-ActReason"/>
      <code value="HTEST"/>
      <display value="test health data"/>
    </security>
  </meta>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml">
      
      <p>
        "Risk of fatal ICH with alteplase for stroke" is a univariate risk estimate.
      </p>
	
    </div>
  </text>
  <url value="http://hl7.org/fhir/Evidence/example-stroke-alteplase-fatalICH"/>
  <identifier>
    <system value="urn:ietf:rfc:3986"/>
    <value value="urn:oid:2.16.840.1.113883.4.642.10.1"/>
  </identifier>
  <name value="RiskOfFatalICHWithAlteplaseForStroke"/>
  <title value="Risk of fatal ICH with alteplase for stroke"/>
  <status value="draft"/>
  <relatedArtifact>
    <type value="citation"/>
    <label value="Emberson 2014"/>
    <display value="Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials."/>
    <citation value="Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063"/>
    <document>
      <url value="https://doi.org/10.1016/S0140-6736(14)60584-5"/>
    </document>
  </relatedArtifact>
  <description value="2.7% incidence of fatal intracranial hemorrhage within 7 days with alteplase in patients with acute ischemic stroke"/>
  <variableDefinition>
    <variableRole>
      <coding>
        <system value="http://terminology.hl7.org/CodeSystem/variable-role"/>
        <code value="population"/>
        <display value="population"/>
      </coding>
    </variableRole>
    <observed>
      <reference value="Group/AcuteIschemicStroke"/>
      <type value="Group"/>
      <display value="adults with acute ischemic stroke"/>
    </observed>
    <intended>
      <reference value="Group/AcuteIschemicStroke"/>
      <type value="Group"/>
      <display value="adults with acute ischemic stroke"/>
    </intended>
  </variableDefinition>
  <variableDefinition>
    <variableRole>
      <coding>
        <system value="http://terminology.hl7.org/CodeSystem/variable-role"/>
        <code value="population"/>
        <display value="population"/>
      </coding>
    </variableRole>
    <observed>
      <reference value="Group/Emberson-2014-IPD-MA-Alteplase-Cohort"/>
      <type value="Group"/>
      <display value="Emberson 2014 IPD-MA Alteplase Cohort"/>
    </observed>
    <intended>
      <reference value="Group/AcuteIschemicStrokeTreatedWithAlteplase"/>
      <type value="Group"/>
      <display value="adults with acute ischemic stroke treated with alteplase"/>
    </intended>
  </variableDefinition>
  <variableDefinition>
    <variableRole>
      <coding>
        <system value="http://terminology.hl7.org/CodeSystem/variable-role"/>
        <code value="measuredVariable"/>
        <display value="measured variable"/>
      </coding>
    </variableRole>
    <observed>
      <reference value="EvidenceVariable/example-fatal-ICH-in-7-days"/>
      <type value="EvidenceVariable"/>
      <display value="fatal ICH"/>
    </observed>
    <intended>
      <reference value="EvidenceVariable/example-fatal-ICH-in-7-days"/>
      <type value="EvidenceVariable"/>
      <display value="fatal ICH"/>
    </intended>
  </variableDefinition>
  <synthesisType>
    <coding>
      <system value="http://terminology.hl7.org/CodeSystem/synthesis-type"/>
      <code value="IPD-MA"/>
      <display value="individual patient data meta-analysis"/>
    </coding>
  </synthesisType>
  <studyDesign>
    <coding>
      <system value="http://hl7.org/fhir/study-design"/>
      <code value="SEVCO:01003"/>
      <display value="randomized assignment"/>
    </coding>
  </studyDesign>
  <statistic>
    <statisticType>
      <coding>
        <system value="http://terminology.hl7.org/CodeSystem/statistic-type"/>
        <code value="C44256"/>
        <display value="Proportion"/>
      </coding>
    </statisticType>
    <quantity>
      <value value="0.026835741669"/>
    </quantity>
    <numberOfEvents value="91"/>
    <sampleSize>
      <numberOfStudies value="9"/>
      <numberOfParticipants value="3391"/>
    </sampleSize>
  </statistic>
</Evidence>