{"certainty":[{"rating":{"coding":[{"code":"high","display":"High quality","system":"http://hl7.org/fhir/certainty-rating"}]},"subcomponent":[{"rating":{"coding":[{"code":"no-concern","display":"no serious concern","system":"http://hl7.org/fhir/certainty-rating"}]},"type":{"coding":[{"code":"RiskOfBias","display":"Risk of bias","system":"http://hl7.org/fhir/certainty-type"}]}},{"description":"Estimated risk from validation calibration plot consistent with predicted risk; observed risk in subgroup with ASTRAL score = 12 consistent with validation calibration plot","rating":{"coding":[{"code":"no-concern","display":"no serious concern","system":"http://hl7.org/fhir/certainty-rating"}]},"type":{"coding":[{"code":"Inconsistency","display":"Inconsistency","system":"http://hl7.org/fhir/certainty-type"}]}},{"rating":{"coding":[{"code":"no-concern","display":"no serious concern","system":"http://hl7.org/fhir/certainty-rating"}]},"type":{"coding":[{"code":"Indirectness","display":"Indirectness","system":"http://hl7.org/fhir/certainty-type"}]}},{"description":"Narrow confidence interval","rating":{"coding":[{"code":"no-concern","display":"no serious concern","system":"http://hl7.org/fhir/certainty-rating"}]},"type":{"coding":[{"code":"Imprecision","display":"Imprecision","system":"http://hl7.org/fhir/certainty-type"}]}},{"rating":{"coding":[{"code":"no-concern","display":"no serious concern","system":"http://hl7.org/fhir/certainty-rating"}]},"type":{"coding":[{"code":"PublicationBias","display":"Publication bias","system":"http://hl7.org/fhir/certainty-type"}]}}],"type":{"coding":[{"code":"Overall","display":"Overall quality","system":"http://hl7.org/fhir/certainty-type"}]}}],"description":"5.3% risk of mRS 3-6 at 90 days","id":"example-ASTRAL-12-alteplase-mRS3-6","identifier":[{"system":"urn:ietf:rfc:3986","value":"urn:oid:2.16.840.1.113883.4.642.10.2"}],"name":"RiskOfMRS36At90DaysAfterAlteplaseForStrokeIfASTRALScore12","relatedArtifact":[{"citation":"Cooray C, Mazya M, Bottai M, Dorado L, Skoda O, Toni D, Ford GA, Wahlgren N, Ahmed N. External Validation of the ASTRAL and DRAGON Scores for Prediction of Functional Outcome in Stroke. Stroke. 2016 Jun;47(6):1493-9. Epub 2016 May 12. PMID 27174528","display":"External Validation of the ASTRAL and DRAGON Scores for Prediction of Functional Outcome in Stroke.","document":{"url":"https://doi.org/10.1161/STROKEAHA.116.012802"},"label":"Cooray 2016 Validation Study","type":"citation"}],"resourceType":"Evidence","statistic":[{"description":"5.3% risk","quantity":{"value":0.0525},"sampleSize":{"note":[{"text":"number of participants describes number in the total study sample, known data count describes number in study sample with ASTRALscore = 12, total number of events describes number of participants with ASTRAL score = 12 and outcome of mRS 3-6 at 90 days"}],"numberOfParticipants":36131},"statisticType":{"coding":[{"code":"C44256","display":"Proportion","system":"http://terminology.hl7.org/CodeSystem/statistic-type"}],"text":"derived proportion"}}],"status":"draft","studyDesign":[{"coding":[{"code":"SEVCO:01016","display":"Uncontrolled cohort design","system":"http://hl7.org/fhir/study-design"}]}],"text":{"div":"<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      \n      <p>\n        &quot;Risk of mRS3-6 at 90 days after Alteplase for Stroke if ASTRAL score 12&quot; is a univariate risk estimate.\n      </p>\n\t\n    </div>","status":"generated"},"title":"Risk of mRS3-6 at 90 days after Alteplase for Stroke if ASTRAL score 12","url":"http://hl7.org/fhir/Evidence/example-ASTRAL-12-alteplase-mRS3-6","variableDefinition":[{"intended":{"display":"patients 0-4.5 hours after acute ischemic stroke onset with ASTRAL score = 12","reference":"Group/ASTRAL-12","type":"Group"},"observed":{"display":"ASTRAL validation cohort","reference":"Group/ASTRAL-Cooray-validation-cohort","type":"Group"},"variableRole":{"coding":[{"code":"population","display":"population","system":"http://terminology.hl7.org/CodeSystem/variable-role"}]}},{"description":"functionally dependent or dead at 3 months","directnessMatch":{"coding":[{"code":"high","display":"High quality match","system":"http://terminology.hl7.org/CodeSystem/directness"}]},"intended":{"display":"Dead or functionally dependent at 90 days","reference":"EvidenceVariable/example-dead-or-dependent-90day","type":"EvidenceVariable"},"observed":{"display":"mRS 3-6 at 90 days","reference":"EvidenceVariable/example-mRS3-6-at-90days","type":"EvidenceVariable"},"variableRole":{"coding":[{"code":"measuredVariable","display":"measured variable","system":"http://terminology.hl7.org/CodeSystem/variable-role"}]}},{"directnessMatch":{"coding":[{"code":"exact","display":"Exact match","system":"http://terminology.hl7.org/CodeSystem/directness"}]},"intended":{"display":"Alteplase for Stroke","reference":"EvidenceVariable/example-alteplase-for-stroke","type":"EvidenceVariable"},"observed":{"display":"Alteplase for Stroke","reference":"EvidenceVariable/example-alteplase-for-stroke","type":"EvidenceVariable"},"variableRole":{"coding":[{"code":"exposure","display":"exposure","system":"http://terminology.hl7.org/CodeSystem/variable-role"}]}}]}