"Alteplase Dosing for Stroke" defines a dosing instruction referenced from an EvidenceVariable resource.

<status value="draft"/> <description value="Alteplase Dosing for Stroke"/> <kind value="MedicationRequest"/> <code> <coding> <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/> <code value="1155608"/> <display value="alteplase injectable product"/> </coding> </code> <intent value="order"/> <dosage> <sequence value="1"/> <text value="give 10% of dose over 1 minute"/> <route> <coding> <system value="http://snomed.info/sct"/> <code value="47625008"/> <display value="Intravenous use"/> </coding> </route> <doseAndRate> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/> <code value="calculated"/> <display value="Calculated"/> </coding> </type> <doseQuantity> <value value="0.9"/> <system value="http://unitsofmeasure.org"/> <code value="mg/kg"/> </doseQuantity> </doseAndRate> <maxDosePerAdministration> <value value="90"/> <system value="http://unitsofmeasure.org"/> <code value="mg"/> </maxDosePerAdministration> </dosage> <dosage> <sequence value="2"/> <text value="give remaining 90% of dose over 1 hour"/> <route> <coding> <system value="http://snomed.info/sct"/> <code value="47625008"/> <display value="Intravenous use"/> </coding> </route> <doseAndRate> <type> <coding> <system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/> <code value="calculated"/> <display value="Calculated"/> </coding> </type> <doseQuantity> <value value="0.9"/> <system value="http://unitsofmeasure.org"/> <code value="mg/kg"/> </doseQuantity> </doseAndRate> <maxDosePerAdministration> <value value="90"/> <system value="http://unitsofmeasure.org"/> <code value="mg"/> </maxDosePerAdministration> </dosage> </ActivityDefinition>