"Alteplase Dosing for Stroke" defines a dosing instruction referenced from an EvidenceVariable resource.

<status value="draft"/><description value="Alteplase Dosing for Stroke"/><kind value="MedicationRequest"/><code><coding><system value="http://www.nlm.nih.gov/research/umls/rxnorm"/><code value="1155608"/><display value="alteplase injectable product"/></coding></code><intent value="order"/><dosage><sequence value="1"/><text value="give 10% of dose over 1 minute"/><route><coding><system value="http://snomed.info/sct"/><code value="47625008"/><display value="Intravenous use"/></coding></route><doseAndRate><type><coding><system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/><code value="calculated"/><display value="Calculated"/></coding></type><doseQuantity><value value="0.9"/><system value="http://unitsofmeasure.org"/><code value="mg/kg"/></doseQuantity></doseAndRate><maxDosePerAdministration><value value="90"/><system value="http://unitsofmeasure.org"/><code value="mg"/></maxDosePerAdministration></dosage><dosage><sequence value="2"/><text value="give remaining 90% of dose over 1 hour"/><route><coding><system value="http://snomed.info/sct"/><code value="47625008"/><display value="Intravenous use"/></coding></route><doseAndRate><type><coding><system value="http://terminology.hl7.org/CodeSystem/dose-rate-type"/><code value="calculated"/><display value="Calculated"/></coding></type><doseQuantity><value value="0.9"/><system value="http://unitsofmeasure.org"/><code value="mg/kg"/></doseQuantity></doseAndRate><maxDosePerAdministration><value value="90"/><system value="http://unitsofmeasure.org"/><code value="mg"/></maxDosePerAdministration></dosage></ActivityDefinition>